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Laboratory factors such as macro-B12 (immunoglobulin-bound B12) can cause spurious elevation on some assays
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[2] The MHRA Drug Safety Update (August 2022) advises healthcare professionals to consider testing vitamin B12 levels in patients taking metformin who develop symptoms of neuropathy or anaemia, and to consider periodic monitoring in those at risk of deficiency
Mechanistic differences: Matrixyl acts as a matrikine -- a peptide fragment derived from extracellular matrix proteins that signals cells to increase collagen synthesis
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